Growth factor program

Vascular endothelial growth factor (VEGF) (sh-Polypeptide-9)
• Follicle formation and hair growth promotion • Cell and tissue growth through vascular development and support • Controls the formation of blood vessels around the hair follicles during hair cycle • Promotes hair growth after hair loss
Insulin like growth factor-1 -1 (IGF-1) (rh-Oligopeptide-2)
• Promotes division of hair matrix cells and keratin forming cells • Delays entry to catagen in hair cycle • Extended hair growth and reduced hair loss
Basic fibroblast growth factor (bFGF2) (sh-Polypeptide-1)
• Formation and maintenance of the blood vessels around the hair follicle cells • Helps formation of skin organs • Protects skin from damage by ultraviolet rays • Promotes anagen

	A delay in hair loss	Promotes hair growth
Hair cycle	Early anagen, Anagen  Catagen	Telogen  Early anagen
Growth factor	IGF-1, Copper peptide-1	IGF1, bFGF, VEGF, TGF-alpha, KGF, HGF

Hair cycle	Growth factor	Function
Early anagen	IGF-1	Promotes division of hair matrix cell
	Copper tripeptide-1	Skin remodeling and hair growth Reduction of 5-α reductase
Anagen	IGF-1	Delays entry to catagen in hair cycle Extends hair growth and reduces hair loss
	bFGF	Induction of anagen
	VEGF	Vessel formation during hair cycle, Increases the thickness of hair

Transforming Growth Factor Beta (TGF-β) (rh-Polypeptie-22)
• Wound healing • Stimulates epidermis cell growth in wound healing • Promotes collagen synthesis, helps wrinkle recovery • Hair growth through the promotion of hair follicle formation
Epidermal growth factor (EGF) (rh-Oligopeptide-1)
• Induces the production of collagen and elastin • Maintains skin elasticity • Helps reduce wrinkles